http://localhost:80/xmlui/handle/123456789/16 2026-04-08T12:31:49Z 2026-04-08T12:31:49Z Ishaque, M http://localhost:80/xmlui/handle/123456789/67 2014-09-03T07:32:06Z 2014-09-03T00:00:00Z

Title: SUKHANVARAN-I-IRAN : Dar 'Asr-I-Hazir' Authors: Ishaque, M

2014-09-03T00:00:00Z Roy (Pal), Rini Das Gupta, Natasha Nag Chaudhuri, Aditi http://localhost:80/xmlui/handle/123456789/20 2014-09-02T06:39:39Z 2014-09-02T00:00:00Z

Title: Designing of less toxic to non targets organophosphorus pesticide : Predicting equation of Acetylcholinesterase activity dependence on LD50 values and octanol-water partition coefficients of the pesticides. Authors: Roy (Pal), Rini; Das Gupta, Natasha; Nag Chaudhuri, Aditi Abstract: Objectives: This paper focuses on the applications of multivariate statistical techniques for designing of cost effective, low non-target nerve damageable Organophosphorus Pesticide (OPs) used in Indian agriculture. They all exhibit anti cholinergic effect on non-targets including mammals. This study would be of great benefit to all people who come into direct as well as indirect contact with pesticides. Methods: In our study, we have dealt with the effects of seven OPs on acetylcholinesterase (AChE) activity in four different parts of rat brain, viz., hypothalamus (H), striatum (S), cerebellum (CR), cerebrum (C). Not all the parts of mammalian brain are equally sensitive to the same pesticide as is evident by direct plotting of inverse of AChE activity vs inverse of LD50 and that of AChE activity vs Pow values1. The statistical model for this study is the 2-way ANOVA. Results: The nature of dependence of AChE activity on pesticide (Pow i.e. octanol water partition coefficient values) and LD50 (lethal dose) is given by Multiple regression Analysis (MRA). This nature has been supported by multiple correlation coefficient values, which indicate the measure of efficacy for different predicting equations. In most of the cases, the results are satisfactory. Conclusions: So through MRA a model pesticide can be designed which is less toxic to non-targets like mammals.

2014-09-02T00:00:00Z Majumdar, Suchandra Nag Chaudhuri, Aditi http://localhost:80/xmlui/handle/123456789/19 2014-09-02T06:34:58Z 2014-09-02T00:00:00Z

Title: SIGNAL TRANSDUCTION PATHWAYS FOR CELL SURVIVAL OR APOPTOSIS BY TRI- AND PENTAVALENT ARSENIC IN RAT BRAIN Authors: Majumdar, Suchandra; Nag Chaudhuri, Aditi Abstract: Arsenate and arsenite affect the brain tissue in a dose independent manner and follow different pathways to exert their toxic effects. Arsenate present in the drinking water is highly toxic at 0.1ppm concentration and causes an array of metabolic disturbances like increased LPO, decreased GSH, increased NOS activity in rat brain. At higher doses also arsenate has damaging effects on biological systems but might follow different mechanism and coadministration of an antioxidant as per normal requirement of rat can control the lipid peroxidation and glutathione level to some extent, but cannot give significant protection against increased nitric oxide synthase activity which eventually causes nuclear changes at DNA or protein level and alter a number of physiological processes in the rat brain. Both arsenate and arsenite significantly affect specific signal transduction molecules in the glial cell population in the brain that are involved in mediating cellular transformation or apoptosis, including MAPKs, NF+kB, PI3K, Akt etc. High concentration of arsenic exposure may lead to apoptosis, whereas a low concentration of arsenic exposure is carcinogenic and may result in aberrant cell accumulation.

2014-09-02T00:00:00Z Roy (Pal), Rini Nag Chaudhuri, Aditi http://localhost:80/xmlui/handle/123456789/18 2014-09-02T06:19:34Z 2014-09-02T00:00:00Z

Title: Towards Less Toxic Organophosphorus Pesticides: Predicting Equation of Acetylcholinesterase Activity Authors: Roy (Pal), Rini; Nag Chaudhuri, Aditi Abstract: This paper focuses on the applications of multivariate statistical techniques for designing cost-effective, low non-target nerve-damageable organophosphorus pesticides (OPs) used in Indian agriculture. The study was done with regard to the effect of seven OPs on acetyl-cholinesterase (AChE) activity in four different parts of rat brain: hypothalamus (H), striatum (S), cerebellum (CR), and cerebrum (C). Not all the parts of mammalian brain are equally sensitive to the same pesticide as was evident by direct plotting of inverse of AChE activity versus inverse of LD50 (lethal dose), and that of AChE activity versus Pow values. The nature of dependence of AChE activity on the pesticide (Pow i.e., octanol water partition coefficient values) and LD50 was determined by multiple regression analysis (MRA). This was supported by multiple correlation coefficient values, which indicate the measure of efficacy for different predicting equations. In most of the cases, the results appeared satisfactory. Thus, using MRA, model pesticides can be designed which are less toxic to non-target organisms such as mammals.

2014-09-02T00:00:00Z